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KMID : 0369819950250040347
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 4 p.347 ~ p.352
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Skin Transport of Synthetic Oligodeoxynucleotide
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Abstract
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Antisense phosphorothioate oligodeoxynucleotide(PS-ODN) against TGF-βin wounded skin. The percutaneous absorption of partially modified PS-ODN(25 mer) was investigated for the purpose of its effective delivery. Though PS-ODN has high molecular
weight
(MW=8,000) and polyanionic change, it was permeated through skin. The skin permeation of PSODN was markedly increased by the removal of stratum corneum and dermis. Moreover, the skin permeation of PS-ODN was decreased in the following order:
hairless
mouse skin> rat skin> human cadaver skin. Thus, PS-ODN represents a logical candidate for further evaluation due to the potential for delivery into the wounded skin.
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